Bruton's tyrosine kinase inhibitors and cardiovascular risk
Doctors now have clearer data showing that a commonly used blood cancer treatment modestly increases heart attack and stroke risk, helping them weigh benefits against cardiovascular safety.
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SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS,…
Researchers identified a new inherited bone marrow disorder caused by faulty DNA-repair genes, opening pathways to understand why some people develop blood cancers earlier in life.
Underserved or high-risk populationsAn N-terminal CDC42 T43I variant reveals the mechanism of pyrin…
Scientists solved a long-standing puzzle about how a specific protein normally prevents dangerous inflammation, revealing why certain mutations trigger severe autoinflammatory disease.
Underserved or high-risk populationsA genotype-first approach reveals the molecular basis of pyrin…
A comprehensive screening of genetic variants in a major inflammation gene reclassifies hundreds of previously unclear mutations, improving diagnostic accuracy for rare autoinflammatory syndromes worldwide.
Novel or significantly improved treatmentCirculating B cell and T cell activation states predict clinical…
Blood immune cell patterns before and during immunotherapy predict which melanoma patients will benefit most and which may experience side effects, enabling personalized treatment planning.