Retrospective Cohort Study of Peripheral Blood miR-486-3p Levels in…
Acute cerebral infarction (ACI) complicated with obstructive sleep apnea syndrome (OSAS) confers a high risk of stroke recurrence and death, yet effective biomarkers for this comorbid condition remain limited. This retrospective cohort study enrolled 270 patients with ACI between November 2020 and December 2023, who were classified into the ACI group (n = 100, apnea‑hypopnea index [AHI] < 5) and the ACI with OSAS group (n = 170, AHI ≥ 5), with the latter further stratified into mild (5 ≤ AHI < 15, n = 60), moderate (15 ≤ AHI < 30, n = 75), and severe (AHI ≥ 30, n = 35) subgroups.
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A clinical decision support system for ECG diagnosis
Automated electrocardiogram (ECG) interpretation is essential for clinical efficiency, yet many existing deep learning (DL) models are perceived as "black boxes" and lack direct benchmarking against established commercial standards. To foster clinician trust and support reimbursement justification, AI systems must demonstrate not only superior accuracy but also alignment with established clinical criteria.
Promising but preliminaryEmerging frontiers and challenges of artificial intelligence in…
Prostate-specific membrane antigen positron emission tomography (PSMA-PET) has become pivotal in prostate cancer (PCa) management, offering superior sensitivity over conventional imaging for detecting tumors, metastases, and biochemical recurrence. However, interpretive subjectivity, workflow inefficiencies, and heterogeneous PSMA expression remain significant limitations.
Near-term implementable findingStandardization and quality control in PET imaging
Positron emission tomography (PET) has transformed diagnostic imaging and therapeutic monitoring by enabling quantitative assessment of molecular processes in vivo. However, reliable use of standardized uptake values (SUVs) and other PET-derived biomarkers requires strict quality assurance (QA), harmonization, and continuous performance monitoring.
Promising but preliminaryDisruption of cellular timekeeping in cancer
Disruption of cellular timekeeping systems is a key driver of cancer cell development and progression. The circadian clock is a 24-hour regulatory system that relies on core clock genes - CLOCK, BMAL1, PER, and CRY.