Daily digest · Tue · 1 Sep 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

AI/ML in clinical diagnostics and imaging

[PMID42674227] · A novel convolution-transformer model for differentiating hypertrophic cardiomyopathy from Phenocopi · 9/10 · The approach demonstrates promising potential for AI-assisted HCM screening and clinical decision support across multi-c

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42674925] · Clonal hematopoiesis and atherosclerotic cardiovascular disease: Clinical implications, biological m · 8/10 · Collectively, CH represents a paradigm shift toward inflammation-driven precision cardiology. [PMID42674889] · Efficacy and safety of olezarsen in patients with vs without baseline fibrate use. · 8/10 · Findings support potential complementary mechanisms and further investigation of concomitant triglyceride-reducing thera [PMID42674554] · The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its com · 8/10 · In this review, we summarize the current evidence on OEA biosynthesis, molecular targets and mechanisms of action, with [PMID42674359] · Mediterranean Diet and Metabolic Outcomes in NAFLD/MASLD: A Systematic Review and Meta-Analysis of R · 8/10 · Heterogeneity was moderate to high across several outcomes (I.

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42674935] · Sixty Years of Lung Cancer Screening: From Sputum Cytology to Low-Dose CT and the Emerging Precision · 8/10 · Lung-RADS has substantially reduced false-positive rates and continues to evolve. [PMID42674877] · [Metastatic or unresectable recurrent anal canal cancer: Therapeutic approaches and emerging perspec · 6/10 · Finally, monitoring HPV circulating tumor DNA (ctDNA) could help optimize patient management, better guide therapy, and [PMID42674718] · Breast MRI With Abbreviated Reading Protocol as Additional Evaluation Tool for Suspicious Microcalci · 6/10 · MIP-only evaluation, does not appear to provide sufficient diagnostic reliability. [PMID42674310] · Non-Invasive Strategy for Gastric Cancer Detection: Integration of Cell-free DNA Fragmentomics and P · 6/10 · The results of the study provide a new avenue for early, accurate, and non-invasive clinical diagnosis of GC. [PMID42674031] · Blocker Primer-Assisted LAMP Coupled with Pyrococcus furiosus Argonaute Enables Specific and Sensiti · 5/10 · These results demonstrate that the blocker primer-assisted LAMP coupled with PfAgo assay is a specific and sensitive app [PMID42673996] · Benchmarking UK Lynch syndrome colonoscopy surveillance: quality metrics and diagnostic yield from t · 5/10 · Our NED evaluation demonstrated high colonoscopy performance in Lynch syndrome, with superior quality and endoscopic yie [PMID42673659] · Oxygen vacancies-induced dual-interface modulation for TiO(2)/BiOI-based photoelectrochemical biosen · 5/10 · To address the issues of poor sensitivity and selectivity in photoelectrochemical (PEC) biosensing for the detection of

Precision oncology and genomic medicine

[PMID42674700] · Transcriptomic Profiling of Adhesion GPCRs in Pancreatic Adenocarcinoma Identifies ADGRG7 and ADGRF1 · 8/10 · Transcriptomic profiles from The Cancer Genome Atlas (TCGA)-PAAD ( We identified a highly distinct aGPCR dysregulation s

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42671999] · Safety of neoadjuvant radiotherapy or chemoradiotherapy combined with immunotherapy across solid tum · 8/10 · This study will synthesize the available evidence on toxicity and perioperative complications and clarify safety risks, [PMID42674877] · [Metastatic or unresectable recurrent anal canal cancer: Therapeutic approaches and emerging perspec · 6/10 · Finally, monitoring HPV circulating tumor DNA (ctDNA) could help optimize patient management, better guide therapy, and [PMID42674045] · In Situ Tracking of Membrane HER2 - Antibody-Drug Conjugate Interaction with Surface Plasmon Resonan · 5/10 · This work establishes cell-based plasmonic imaging as a quantitative and mechanistic approach for evaluating ADC-recepto

Aging, longevity, and population health

[PMID42670437] · A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strateg · 8/10 · The proposed development sequence prioritizes pharmacokinetic characterization, safety, target engagement, biomarker-def

CBC-based diagnostics and machine learning in hematology

No high-priority finds today (best candidate scored 0/10)

Rare diseases with high unmet need

No high-priority finds today (best candidate scored 7/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

[PMID42673525] · Proteomics in the discovery of biomarkers of major complications after allogeneic hematopoietic cell · 7/10 · Treatment Innovation [PMID42671911] · Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation. · 7/10 · Treatment Innovation [PMID42671879] · Primary Plasma Cell Leukemia. · 7/10 · Treatment Innovation [PMID42671976] · Estimating the proportion of transplant-eligible patients in diffuse large b-cell lymphoma (DLBCL): · 6/10 · Treatment Innovation [PMID42671910] · Tumor CD19 Expression Determines Distinct Clinical Outcomes After CD19 CAR T-Cell Therapy in Large B · 6/10 · Treatment Innovation

AI/ML in clinical diagnostics and imaging

[PMID42673682] · Utility of artificial intelligence for identifying thoracic lymphadenopathy in lung cancer. · 7/10 · Diagnostics [PMID42671965] · AI-Assisted Sonography for the Diagnosis of Thyroid Nodules. · 7/10 · Diagnostics [PMID42674709] · Integration of Artificial Intelligence Models and Logistic Regression to Increase the Diagnostic Acc · 6/10 · Diagnostics [PMID42674284] · Accelerated Cardiac MRI Using Deep Learning Cine Imaging: Validation in Pediatric Patients both with · 6/10 · Diagnostics [PMID42674130] · Large Language Models vs. NASS Common Coding Scenarios: An Analysis of Accuracy and Financial Implic · 6/10 · Diagnostics

Precision oncology and genomic medicine

[PMID42674932] · Landscape of Actionable Genetic Alterations in Advanced Urothelial Carcinoma: High Prevalence but Li · 7/10 · Treatment Innovation [PMID42674822] · ERP44 Is Associated With Poor Prognosis and Promotes Proliferation and Temozolomide Resistance in Lo · 7/10 · Treatment Innovation [PMID42674823] · Mutual Information-based Prognostic Biomarker Discovery in Cancer Genomics: Conceptual Framework and · 6/10 · Diagnostics [PMID42674820] · Multi-level Transcriptomic and Machine-learning Analyses Identify MZT1 as a Proliferation-associated · 6/10 · Diagnostics [PMID42674724] · Association Between Kita-Kyushu Lung Cancer Antigen-1 Positivity and Pathological High-grade Lung Ad · 6/10 · Treatment Innovation

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42674818] · Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer. · 7/10 · Treatment Innovation [PMID42673705] · Lenvatinib plus pembrolizumab for the treatment of patients with non-BRAF mutated anaplastic thyroid · 7/10 · Treatment Innovation [PMID42674689] · Early LMR Dynamics and AFP Status in Advanced HCC Treated With Atezolizumab/Bevacizumab. · 6/10 · Treatment Innovation [PMID42674706] · Patterns of Response to Durvalumab Plus Tremelimumab and Atezolizumab Plus Bevacizumab in Patients W · 6/10 · Treatment Innovation [PMID42673464] · Interpreting vaccine-associated survival differences in immune checkpoint inhibitor therapy. · 6/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42674899] · Microvascular and macrovascular complications of diabetes in people with HIV. · 7/10 · Diagnostics [PMID42674726] · Antiproteinuric Effect of SGLT2 Inhibitors in Patients With Hepatocellular Carcinoma Receiving Atezo · 7/10 · Treatment Innovation [PMID42675010] · Barriers and facilitators of cardiovascular disease prevention among people with HIV in the Southern · 6/10 · Diagnostics [PMID42674302] · Association between lithium treatment and vascular calcification in bipolar disorder: A retrospectiv · 6/10 · Treatment Innovation [PMID42674321] · Structural characterization and mechanisms of anti-diabetic activity of a novel polysaccharide with · 5/10 · Treatment Innovation

Aging, longevity, and population health

[PMID42671457] · Inflammaging and cytokine-driven cardiovascular senescence in age-related myocardial infarction: mec · 7/10 · Treatment Innovation [PMID42671002] · Robotic Surgery in Australasian Gynaecology: Results of a 2025 Cross-Sectional Survey. · 7/10 · Diagnostics [PMID42674422] · The first high pathogenicity avian influenza A(H5N1) clade 2.3.4.4b incursions in the Hunter New Eng · 5/10 · Diagnostics [PMID42672066] · Association between sense of coherence and loss of independence or death in older adults: Locomotive · 5/10 · Diagnostics [PMID42670822] · Climate Exposures Increase the Risk of Anemia Among Reproductive-Age Women in Low- and Middle-Income · 4/10 · Public Health

Rare diseases with high unmet need

[PMID42674209] · Rare disease benchmarks: investment professionals' accuracy and beliefs. · 7/10 · Genomics/Precision Medicine [PMID42670341] · [Upper tract urothelial carcinoma - regional differences observed in several quality indicators]. · 6/10 · Treatment Innovation [PMID42674804] · Follicular Granular Parakeratosis of the Face and Neck. · 4/10 · Other [PMID42674778] · Intrapulmonary percussive ventilation for the management of destroyed lung in Swyer-James-MacLeod sy · 4/10 · Diagnostics [PMID42669913] · Clinical features, genetic analysis, and efficacy evaluation of hematopoietic stem cell transplantat · 4/10 · Treatment Innovation

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42674905] · Passive digital monitoring via mobile apps and wearables in multiple sclerosis: A systematic review. · 6/10 · Early Detection [PMID42674350] · Process evaluation of a national initiative to detect cancer early in Scotland. · 6/10 · Early Detection [PMID42673809] · Knowledge and attitudes of intensive care unit nurses toward pressure ulcer prevention: A mixed-meth · 6/10 · Early Detection [PMID42673681] · AI-based tools for predicting and early diagnosis of graft rejection in solid organ transplantation · 6/10 · Early Detection [PMID42674880] · Graph-Based Neural Network for Malignancy Detection in Breast Ultrasound Images using Medically Sign · 5/10 · Early Detection

💡 UNSOLICITED FINDS

[PMID42674805] · Prognostic significance of stress hyperglycemia ratio in patients undergoing percutaneous coronary i · 9/10 [PMID42674969] · Geographic variation in long-term health outcomes following myocardial infarction in England. · 8/10

📊 TODAY'S BREAKDOWN

By research category: Diagnostics: 33, Early Detection: 15, Genomics/Precision Medicine: 4, Other: 1, Public Health: 1, Treatment Innovation: 46
By evidence maturity: Exploratory: 63, Potentially Practice-Changing: 7, Validated: 30
By watchlist topic: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed=15, high=1, best_score=8 CBC-based diagnostics and machine learning in hematology: reviewed=0, high=0, best_score=0 Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed=15, high=1, best_score=8 AI/ML in clinical diagnostics and imaging: reviewed=15, high=1, best_score=9 Precision oncology and genomic medicine: reviewed=15, high=1, best_score=8 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed=15, high=1, best_score=8 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed=15, high=4, best_score=8 Aging, longevity, and population health: reviewed=6, high=1, best_score=8 Rare diseases with high unmet need: reviewed=5, high=0, best_score=7 Sentinel scan: reviewed=10, high=2, best_score=9
By source type: peer_reviewed 100 | preprint 0
Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, Rare diseases with high unmet need

🔧 RUN NOTES

CBC-based diagnostics and machine learning in hematology: primary query returned 0 results; used fallback query.