A novel convolution-transformer model for differentiating…
Hypertrophic Cardiomyopathy (HCM) is the most prevalent inherited cardiomyopathy. Its left ventricular hypertrophy (LVH) phenotype exhibits substantial radiological overlap with HCM phenocopies such as Hypertensive Heart Disease (HHD) and Cardiac Amyloidosis (CA), posing significant challenges to clinical differential diagnosis.
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Prognostic significance of stress hyperglycemia ratio in patients…
Stress hyperglycemia is common during percutaneous coronary intervention (PCI) and is associated with worse outcomes. The stress hyperglycemia ratio (SHR), which standardizes acute glucose levels to chronic glycemic status, may provide superior prognostic information compared with admission glucose alone.
Promising but preliminaryClonal hematopoiesis and atherosclerotic cardiovascular disease
Clonal hematopoiesis (CH), defined by the age-related expansion of hematopoietic stem cells harboring somatic driver mutations, has emerged as a novel and clinically relevant contributor to atherosclerotic cardiovascular disease (ASCVD). Once considered primarily a precursor to hematologic malignancy, CH is now recognized as a systemic pro-inflammatory state linking somatic evolution to cardiovascular pathology.
Early cancer detection or preventionSixty Years of Lung Cancer Screening
To trace the evolution of lung cancer screening from early radiographic and sputum cytology trials through the landmark randomized trials that established low-dose computed tomography (LDCT) as a guideline-endorsed intervention, and to examine emerging technologies poised to transform the field. A narrative synthesis of primary trial literature, guideline documents, and emerging research conducted March-May 2026.
Promising but preliminaryTranscriptomic Profiling of Adhesion GPCRs in Pancreatic…
Pancreatic adenocarcinoma (PAAD) is characterized by a desmoplastic, profoundly immunosuppressive tumor microenvironment (TME). Adhesion G protein-coupled receptors (aGPCRs) regulate cell-matrix interactions and immune modulation, yet their specific roles in PAAD remain poorly understood.