📅 PUBMED DAILY TRIAGE — 2026-09-07 Window: 2026-09-06T09:00:00Z → 2026-09-07T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 84 | Candidates evaluated: 84 High priority: 14 | Standard: 54 | Low/archive: 16 | Unsolicited finds: 8 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PM42702241 · Acute leukemia therapy at a crossroads: from conventional chemotherapy to the er · 8/10 · 🟠 Novel or significantly improved treatment Simultaneously, for acute lymphoblastic leukemia (ALL), in addition to the significant improvements achieved by tyrosine
CBC-based diagnostics and machine learning in hematology
No high-priority finds today (best candidate scored 0/10)
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PM42701198 · Integrating molecular subtypes, genomics and functional dependencies to identify · 8/10 · 🟢 Near-term implementable finding _Overall, this review highlights both the opportunities and challenges associated with molecular stratification in small _
- PM42702327 · Translational optical and electrochemical biosensing strategies for liquid biops · 8/10 · 🔴 Early cancer detection or prevention Finally, this review emphasizes future integration of biosensors with CTC-derived organoids, microfluidics, AI, and mult
- PM42701426 · Exercise-associated epigenetic remodeling and TCR repertoire dynamics in Lynch s · 7/10 · 🔴 Early cancer detection or prevention TCR analysis reveals an exercise-associated increase in systemic repertoire diversity and tissue-specific clonal converg
- PM42701973 · Radiology considerations for the PREMIUM study: a multicenter randomized control · 7/10 · 🔴 Early cancer detection or prevention PREMIUM aims to determine whether screening for HCC with a DCE aMRI protocol reduces HCC-related mortality and also faci
- PM42702456 · Engineered E. coli biosensor with dual-module sensing and signal amplification f · 5/10 · 🔴 Early cancer detection or prevention This work demonstrates a significant advance toward a non-invasive, user-friendly, microbe-based point-of-care diagnosti
- PM42701956 · Cancer risk and mortality assessment in the overweight population: evaluation of · 5/10 · 🔴 Early cancer detection or prevention Combined multi-biomarker models deliver limited predictive improvement yet can aid population risk stratification.
- PM42702023 · Improving dermatology tele-expertise through physician training: evidence from a · 5/10 · 🔴 Early cancer detection or prevention This resulted in more efficient specialist responses.
- PM42701833 · Completeness and Timeliness of Diagnostic Follow-up for Mammograms in Palau, 201 · 5/10 · 🔴 Early cancer detection or prevention Strengthening routine monitoring of follow-up indicators is recommended to support continuous quality improvement.
AI/ML in clinical diagnostics and imaging
- PM42701973 · Radiology considerations for the PREMIUM study: a multicenter randomized control · 7/10 · 🔴 Early cancer detection or prevention PREMIUM aims to determine whether screening for HCC with a DCE aMRI protocol reduces HCC-related mortality and also faci
Precision oncology and genomic medicine
- PM42702211 · Targeted therapies in advanced non-small-cell lung cancer: new biomarkers and tr · 6/10 · 🟠 Novel or significantly improved treatment Newer generations of tyrosine kinase inhibitors, the introduction of bispecific antibodies, and antibody-drug conjugates
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PM42702517 · Incremental risk of high-grade adverse events with immune checkpoint inhibitors · 9/10 · 🟢 Near-term implementable finding In the absence of validated predictive biomarkers or a demonstrated overall survival benefit, poly(adenosine diphosphate
- PM42702389 · [Advances in intravesical therapy for non-muscle-invasive bladder cancer]. · 6/10 · 🟠 Novel or significantly improved treatment Antibody-drug conjugates (ADCs), such as RC-48, have shown favorable antitumor activity in selected patient populations.
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PM42701458 · Comparative effectiveness of GLP-1 receptor agonists versus mineralocorticoid re · 8/10 · 🟢 Near-term implementable finding _INTERPRETATION: In our retrospective study, among adults with resistant hypertension and overweight or obesity, GLP-1RA _
- PM42701883 · Prospective Evaluation of Quality-of-Life Improvement After Dapagliflozin Initia · 8/10 · 🟢 Near-term implementable finding Although benefits are observed in most patients, individuals aged > 65 years, with prior myocardial infarction, or recen
Aging, longevity, and population health
No high-priority finds today (best candidate scored 7/10)
Rare diseases with high unmet need
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- PM42701678 · Acupoint Selection Patterns and Potential Mechanisms of Acupuncture in · 5/10 · Treatment Innovation
- PM42702380 · [Deubiquitinase USP30 alleviates brain injury after intracerebral hemo · 5/10 · Treatment Innovation
- PM42702174 · Targeting the myeloid immune checkpoint ILT3 (LILRB4) with small molec · 5/10 · Treatment Innovation
- PM42702564 · Aberrant Expression of Multiple T-Cell Markers in Primary Cutaneous Fo · 4/10 · Treatment Innovation
- PM42701816 · Clinical Spectrum, Diagnostic Work-up, and Outcomes of Neurolymphomato · 4/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- PM42701397 · Toll-like receptor 9-overexpressing red blood cell biomimetic microbub · 5/10 · Early Detection
AI/ML in clinical diagnostics and imaging
- PM42701562 · Artificial intelligence in computed tomography imaging for pulmonary e · 6/10 · Diagnostics
- PM42701617 · Has computer-aided diagnosis now outperformed radiologists in the accu · 6/10 · Diagnostics
- PM42701602 · Implementation of an artificial intelligence-based system for mammogra · 6/10 · Diagnostics
- PM42701528 · Quantitative generation of diffusion-weighted imaging from non-contras · 6/10 · Diagnostics
- PM42701524 · Impact of CT slice thickness reduction algorithm on AI-based lung nodu · 6/10 · Diagnostics
Precision oncology and genomic medicine
- PM42701157 · Metabolic convergence of diabetes and prostate cancer: from dysglycemi · 6/10 · Genomics/Precision Medicine
- PM42702361 · Machine Learning-Derived Immune Gene Signature Predicts Prognosis and · 6/10 · Genomics/Precision Medicine
- PM42702190 · Spatiotemporal decoding of the pre-metastatic niche: Multi-omics innov · 6/10 · Genomics/Precision Medicine
- PM42701405 · A protocol for evaluating robustness to H&E staining variation in comp · 5/10 · Genomics/Precision Medicine
- PM42702321 · Structural characterization and predicted biosynthetic pathway of the · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- PM42701658 · Baseline Gustave Roussy Immune Score and Survival in Extensive-Stage S · 6/10 · Treatment Innovation
- PM42701638 · Depletion of Soluble PD-L1 with Engineered Nanoparticles Promotes Anti · 6/10 · Treatment Innovation
- PM42701121 · Translational modelling challenges receptor‑occupancy‑based dosing of · 5/10 · Treatment Innovation
- PM42701943 · Lactate-associated H3K18la upregulates RNF166 to promote immune evasio · 5/10 · Treatment Innovation
- PM42702210 · Early-stage non-small-cell lung cancer: emerging treatments and evolvi · 4/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- PM42701941 · Lean Mass Reduction During Glucagon-like Peptide-1 Receptor Agonists-I · 6/10 · Prevention
- PM42702012 · Glucagon-like Peptide-1 receptor agonist use is associated with decrea · 6/10 · Prevention
- PM42701351 · The Evolution of Medications for Obesity Management. · 6/10 · Prevention
- PM42701460 · Preoperative Weight Loss Before Total Joint Arthroplasty Using Novel G · 5/10 · Prevention
- PM42701986 · Association of coexposure to indoor solid fuels, outdoor air pollution · 4/10 · Prevention
Aging, longevity, and population health
- PM42701998 · Growth Hormone Receptor Antagonism Extends Lifespan. · 7/10 · Public Health
- PM42702379 · Life's Essential 10 and brain health: A prospective cohort study. · 6/10 · Public Health
- PM42701880 · Burden dynamics of pulmonary arterial hypertension in China and the G2 · 5/10 · Public Health
- PM42701914 · Shift work, accelerated biological aging and mortality risk in US adul · 5/10 · Public Health
- PM42701855 · [Generational Differences Among Italian Nephrology Nurses: A Cross-Sec · 4/10 · Public Health
Rare diseases with high unmet need
- PM42701435 · Artificial intelligence-assisted clinical exome sequencing: Insights a · 6/10 · Drug Development
- PM42701364 · Primary Chest Wall Malignant Lymphoma in a Patient Without a History o · 4/10 · Treatment Innovation
- PM42701434 · Sporadic lymphangioleiomyomatosis with lymphocyte-predominant pleural · 4/10 · Drug Development
- PM42702390 · [A rare case of Rosai-Dorfman disease involving the pituitary stalk an · 4/10 · Drug Development
💡 UNSOLICITED FINDS
- PM42702214 [STANDARD] · Induction and consolidation atezolizumab with stereotactic body radiation therap · 7/10 · 🟢 Near-term implementable finding
- PM42701166 [STANDARD] · Functional outcomes following psychotherapy for elevated suicide risk: Secondary · 7/10 · 🟢 Near-term implementable finding
- PM42701496 [STANDARD] · Influence of Protein Intake during Obesity Reduction on Physical Function and Bo · 7/10 · 🟢 Near-term implementable finding
- PM42702374 [STANDARD] · [Deep learning models based on fused ultrasound images for the assessment of cys · 5/10 · ⚪ Promising but preliminary
- PM42701552 [STANDARD] · Clinical prognostic value of imaging and immuno-hormonal markers in uterine leio · 4/10 · ⚪ Promising but preliminary
- PM42701682 [STANDARD] · Stakeholders' perspectives on an autonomous brain MRI: An interview study. · 4/10 · ⚪ Promising but preliminary
- PM42701493 [STANDARD] · A radiomics-based machine learning model for the preoperative differentiation of · 4/10 · ⬜ Standard addition
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 28
- Genomics/Precision Medicine: 13
- Early Detection: 10
- Diagnostics: 9
- Other: 8
- Prevention: 7
- Public Health: 6
- Drug Development: 3
By evidence maturity:
- Exploratory: 56
- Validated: 23
- Potentially Practice-Changing: 5
By watchlist topic (reviewed / kept / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 13 / 1 high / 8/10
- CBC-based diagnostics and machine learning in hematology: 0 / 0 high / 0/10
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 10 / 8 high / 8/10
- AI/ML in clinical diagnostics and imaging: 10 / 1 high / 7/10
- Precision oncology and genomic medicine: 13 / 1 high / 6/10
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 / 2 high / 9/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 7 / 2 high / 8/10
- Aging, longevity, and population health: 6 / 0 high / 7/10
- Rare diseases with high unmet need: 4 / 0 high / 6/10
By source type: peer_reviewed 84 | preprint 0
Topics with zero HIGH articles this run: CBC-based diagnostics and machine learning in hematology, Aging, longevity, and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- T2 (CBC-based diagnostics and ML): 0 results for both primary and fallback queries.
- T6 (Novel therapeutics) raw=23, capped at 15 per-topic review limit.
- Sentinel raw=49, capped at 10 per run rules.
- Post-processing removed 2 articles: ['42702146', '42702055']
- Score corrections applied for PMID 42701397 (cfDNA liver IRI study misclassified as cancer early detection).