Cervical Cord Compression-Induced Hypertension
Decompression surgery has been reported to attenuate hypertension in patients with cervical cord stenosis; however, the causal relationship and underlying neurobiological mechanisms remain unclear. We investigated whether cervical spinal cord compression induces blood pressure (BP) elevation and evaluated the therapeutic effects of decompression in a rodent model.
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Molecular residual disease
Molecular residual disease (MRD), detected via circulating tumor DNA (ctDNA) after curative-intent surgery, identifies resectable solid tumor patients at high recurrence risk, thereby enabling enriched trials with larger effect sizes and smaller samples. Yet enrichment narrows the eligible population and thus challenges conventional randomized designs.
Promising but preliminaryUnveiling the Gastric Microbiome
Gastric cancer (GC) remains a major global health burden and is frequently diagnosed at advanced stages owing to the limited sensitivity, invasiveness, and restricted availability of current screening strategies. Increasing evidence indicates that the gastric microbiome including Helicobacter pylori and diverse non-H.
Near-term implementable findingVitamin D supplementation for pediatric steatotic liver disease
This review aimed to systematically evaluate the evidence from interventional studies for the effects of vitamin D supplementation on hepatic and metabolic parameters in children with metabolic dysfunction-associated steatotic liver disease (MASLD). MEDLINE, Scopus, Web of Science, and clinical trial registers were systematically searched using MeSH terms until April 30, 2025.
Promising but preliminaryIntegrating machine learning and GWAS for variant prioritization in…
Chronic kidney disease (CKD) is a major public health challenge, affecting approximately 674 million people worldwide and representing one of the fastest-growing causes of mortality. Since CKD is frequently asymptomatic in its early stages, the identification of novel genetic biomarkers may improve early detection and risk stratification.