Daily digest · Tue · 15 Sep 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42735678] · Molecular residual disease: Charting a new path for treating resectable solid tumors. · 9/10 · We propose an MRD Registry as an external control cohort that integrates quantitative ctDNA data with outcomes to valida [PMID42734869] · Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Ca · 9/10 · Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions [PMID42736084] · Beyond conventional lipid panel: Estimated small dense and triglyceride-rich LDL cholesterol are ass · 8/10 · These accessible markers may provide complementary, independent information for early risk stratification using routine [PMID42735168] · Parametric Quantitative Ultrasound-Based Deep Learning for Breast Cancer Diagnosis. · 8/10 · These results are promising for the incorporation of physics-based QUS features into deep learning frameworks to improve [PMID42734913] · Cost-Effectiveness of Smoking Cessation Interventions Integrated Into Lung Cancer Screening. · 7/10 · These findings may be useful for health systems to guide decisions, while considering budget and capacity, on the modali [PMID42735774] · Beyond copy number: circulating cell-free mitochondrial DNA Fragmentomics and structural states in l · 5/10 · The central implication is that the next phase of cf-mtDNA diagnostics will depend less on measuring more DNA than on me [PMID42735584] · 3D-printed spiral and contraction-expansion array cascaded microfluidic chip combined with ICP-MS fo · 5/10 · The system operates without external fields or blood pre-treatment, relying solely on size-dependent inertial focusing t

AI/ML in clinical diagnostics and imaging

[PMID42734869] · Unveiling the Gastric Microbiome: Novel Insights into Early Detection and Pathogenesis of Gastric Ca · 9/10 · Finally, the review discusses therapeutic avenues including microbiota modulation, immunotherapy microbiome interactions [PMID42735168] · Parametric Quantitative Ultrasound-Based Deep Learning for Breast Cancer Diagnosis. · 8/10 · These results are promising for the incorporation of physics-based QUS features into deep learning frameworks to improve [PMID42736093] · Deep Learning Based on Magnetic Resonance Imaging for Preoperative Prediction of Pituitary Neuroendo · 8/10 · MRI-based deep learning enables accurate preoperative PitNET subtyping in retrospective cohorts, warranting investigatio [PMID42735713] · Looking to the Future: How Will Personalised Medicine Impact Facial Plastic Surgery. · 8/10 · Its future value will depend on thoughtful integration into practice as an adjunct to, rather than a replacement for, su [PMID42734878] · Artificial intelligence in trigeminal neuralgia: trigeminal nerve segmentation and neurovascular con · 8/10 · The high specificity and diagnostic odds ratio suggest that AI can play a critical role in enhancing clinical decision-m [PMID42734638] · Thrombospondin-1 as a Mechanosensitive Matrix Protein Driving Fibroblast Senescence: A Novel Pathoge · 8/10 · THBS1 mediates stress-induced pelvic floor degeneration by promoting fibroblast senescence and disrupting ECM homeostasi [PMID42734633] · Pharmacogenomics and artificial intelligence in cardiovascular disease: emerging tools for precision · 8/10 · PubMed, Google Scholar, Scopus, and Web of Science were searched for relevant literature published from 1990 to 2026, wi

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

[PMID42736049] · Vitamin D supplementation for pediatric steatotic liver disease: A systematic review and meta-analys · 8/10 · Future trials examining vitamin D for pediatric MASLD and exploring subgroups further benefiting from the intervention m [PMID42734831] · Defining and managing high-risk acute myeloid leukemia (AML) in 2026. · 7/10 · Improving outcomes will require integration of precision diagnostics, biologically informed therapy, and adaptive strate [PMID42734838] · Optimizing venetoclax duration with hypomethylating agents for newly diagnosed acute myeloid leukemi · 6/10 · These findings support further prospective evaluation of reduced VEN durations in this population. [PMID42734350] · Concordance of Flow Cytometry and Real-Time Quantitative Polymerase Chain Reaction for Measurable Re · 5/10 · These findings highlight the need for continuous quality assurance, national reference laboratories, dedicated MRD labor

CBC-based diagnostics and machine learning in hematology

[PMID42733719] · Integrating machine learning and GWAS for variant prioritization in the INCIPE cohort highlights ABC · 8/10 · Overall, these findings support the integration of ML with GWAS to prioritize candidate genes and investigate the geneti

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42736084] · Beyond conventional lipid panel: Estimated small dense and triglyceride-rich LDL cholesterol are ass · 8/10 · These accessible markers may provide complementary, independent information for early risk stratification using routine

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42736101] · An integrated Phase II/III randomized study comparing durvalumab and tremelimumab ± Hepatic ArteriaL · 8/10 · Progression to phase III will depend on a predefined futility rule based on the ORR observed in the experimental arm.

Rare diseases with high unmet need

[PMID42734439] · Identifying methodological guidance used for systematic reviews, clinical practice guidelines, and h · 8/10 · OSF https://osf. io/mrfev.

Precision oncology and genomic medicine

[PMID42735774] · Beyond copy number: circulating cell-free mitochondrial DNA Fragmentomics and structural states in l · 5/10 · The central implication is that the next phase of cf-mtDNA diagnostics will depend less on measuring more DNA than on me

Aging, longevity, and population health

No high-priority finds today (best candidate scored 6/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Early cancer detection (liquid biopsy, ctDNA, cfDNA)

[PMID42735552] · Reverse-engineering the diagnostic process: An indirect finding-driven deep learning model for pelvi · 7/10 · Early Detection [PMID42736172] · Early Detection of Deep Tissue Pressure Injury in Intensive Care Using Hemodynamics-Based Machine Le · 6/10 · Early Detection [PMID42735960] · A narrative review of artificial intelligence applications in type B aortic dissection. · 6/10 · Early Detection [PMID42734835] · HRKHu-Loss: harmonic regularization Kullback Huber loss-based lung cancer detection and severity lev · 6/10 · Early Detection [PMID42735766] · Generation and evaluation of nanobodies specific for virulence proteins from Vibrio parahaemolyticus · 5/10 · Early Detection

Precision oncology and genomic medicine

[PMID42735563] · ACAD8-mediated valine catabolism inhibits mTOR signaling to suppress lipid accumulation and progress · 7/10 · Treatment Innovation [PMID42736094] · Feasibility of CEUS LI-RADS Nonradiation Treatment Response Assessment for Early Evaluation of Intra · 6/10 · Treatment Innovation [PMID42735911] · Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer. · 6/10 · Treatment Innovation [PMID42735848] · PTEN-Long-mediated molecular therapy: current evidences and future perspectives. · 6/10 · Diagnostics [PMID42735562] · An immune related cell death index for prognostic stratification and immunotherapy response predicti · 6/10 · Treatment Innovation

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

[PMID42736173] · Active and Non-Active Comparators Yield Different Estimates of the Association Between Proton Pump I · 7/10 · Diagnostics [PMID42735913] · Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategie · 7/10 · Treatment Innovation [PMID42735561] · Reversing sarcopenia with megestrol acetate ameliorates systemic inflammation and improves survival · 7/10 · Treatment Innovation [PMID42735911] · Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer. · 6/10 · Treatment Innovation [PMID42735562] · An immune related cell death index for prognostic stratification and immunotherapy response predicti · 6/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[PMID42736042] · GLP-1 Receptor Agonist-Based Prandial Insulin De-Intensification in Outpatients With Type 2 Diabetes · 7/10 · Treatment Innovation [PMID42735804] · GLP-1 receptor agonists, epigenetic aging, and the prospect of pharmacological healthspan extension. · 7/10 · Treatment Innovation [PMID42736034] · Sex-Stratified Associations of DXA-Derived Adiposity, Regional Fat Distribution and Muscle Power Wit · 6/10 · Diagnostics [PMID42736030] · Real-World Cost and Utilisation Burden of Diagnosed Metabolic Dysfunction-Associated Steatotic Liver · 6/10 · Diagnostics [PMID42736027] · Psychiatric Safety of GLP-1 and Dual GIP/GLP-1 Receptor Agonists in Adolescents With Obesity. · 6/10 · Prevention

Rare diseases with high unmet need

[PMID42733297] · Population Prevalence and Incident HPA-1a Alloimmunisation in Pregnancy: A Prospective, Multi-Ethnic · 7/10 · Diagnostics [PMID42735473] · Drug repurposing of glycerol phenylbutyrate for children with SLC6A1-related neurodevelopmental diso · 5/10 · Treatment Innovation [PMID42736041] · Peritoneal Dialysis for End-Stage Kidney Disease due to Mitochondrial Encephalopathy, Lactic Acidosi · 4/10 · Diagnostics [PMID42735017] · [Tracheal diverticulum: clinical features, diagnosis, and surgical treatment]. · 4/10 · Treatment Innovation

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

[PMID42735000] · Clinical management of clonal hematopoiesis. · 6/10 · Diagnostics [PMID42734717] · Detection of a Nirsevimab-Resistant RSV-B Variant (F:K68Q) in an Adult with Severe Infection. · 6/10 · Treatment Innovation [PMID42733996] · Genetic Mutations in Patients with Acute Myeloid Leukemia and Their Impact on Prognosis. · 6/10 · Diagnostics [PMID42735211] · Strength Training Exercises to Minimize Late Effects of Childhood Leukemia or Lymphoma Among Adolesc · 5/10 · Diagnostics [PMID42736051] · New Annular, Indurated Plaques During Mogamulizumab Therapy in Cutaneous T-Cell Lymphoma: A Clinicop · 4/10 · Treatment Innovation

CBC-based diagnostics and machine learning in hematology

[PMID42736071] · The Role of Baseline Systemic Inflammatory Indices Predicting Long-Term Mortality in Kidney Transpla · 6/10 · Diagnostics

AI/ML in clinical diagnostics and imaging

[PMID42734835] · HRKHu-Loss: harmonic regularization Kullback Huber loss-based lung cancer detection and severity lev · 6/10 · Early Detection [PMID42736115] · [Artificial intelligence empowering spinal deformity surgery: from clinical assessment to decision i · 6/10 · Treatment Innovation [PMID42736095] · Who Read It First? Documenting Independent Judgment in AI-Assisted Radiology. · 6/10 · Diagnostics [PMID42735788] · Development of an AI-Based Smartphone Application for Rapid Tick Identification and Geospatial Mappi · 6/10 · Diagnostics [PMID42735236] · Artificial intelligence in liver transplant allocation: Promise, pitfalls, and ethical safeguards. · 6/10 · Diagnostics

Aging, longevity, and population health

[PMID42735917] · Bladder Antimuscarinic Use and Cognitive Impairment in Adults Aged 75 Years or Older With Urinary In · 6/10 · Treatment Innovation [PMID42734009] · Age and Gender-Related Trajectories of Urine Osmolality in a Large-Scale Population Study: Physiolog · 6/10 · Diagnostics [PMID42733378] · [Growth hormone and fertility: molecular mechanisms and experience of adjuvant therapy in reproducto · 6/10 · Diagnostics [PMID42735077] · Understanding the Psychology, Genetics, and Neurobiology of Happiness with Clinical Implications. · 5/10 · Diagnostics [PMID42734767] · Characterization of the Senescence-Associated Secretory Phenotype in Primary and Induced Pluripotent · 5/10 · Treatment Innovation

💡 UNSOLICITED FINDS

[PMID42735860] · Cervical Cord Compression-Induced Hypertension: A Treatable Neurogenic Vascular Disorder. · 10/10 [PMID42735969] · Impact of Diabetes on Outcomes of Contemporary PCI Guided by OCT vs Angiography: The ILUMIEN IV Tria · 8/10

📊 TODAY'S BREAKDOWN

By research category: Diagnostics: 33, Early Detection: 16, Genomics/Precision Medicine: 1, Other: 2, Prevention: 2, Treatment Innovation: 42
By evidence maturity: Exploratory: 58, Potentially Practice-Changing: 11, Validated: 27
By watchlist topic: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed=15, high=1, best_score=8 CBC-based diagnostics and machine learning in hematology: reviewed=2, high=1, best_score=8 Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed=15, high=4, best_score=9 AI/ML in clinical diagnostics and imaging: reviewed=15, high=7, best_score=9 Precision oncology and genomic medicine: reviewed=15, high=0, best_score=7 Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed=15, high=1, best_score=8 Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed=15, high=1, best_score=8 Aging, longevity, and population health: reviewed=6, high=0, best_score=6 Rare diseases with high unmet need: reviewed=5, high=1, best_score=8 Sentinel scan: reviewed=10, high=2, best_score=10
By source type: peer_reviewed 96 | preprint 0
Topics with zero 8+ articles this run: Precision oncology and genomic medicine, Aging, longevity, and population health

🔧 RUN NOTES

Clean run, no issues.