📅 PUBMED DAILY TRIAGE — 2026-09-23 Window: 2026-09-22T09:00:00Z → 2026-09-23T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 107 | Candidates evaluated: 107 High priority: 29 | Standard: 75 | Low/archive: 3 | Unsolicited finds: 9 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
- No high-priority finds today (best candidate scored 6/10)
CBC-based diagnostics and ML in hematology
- No high-priority finds today (best candidate scored 6/10)
Early cancer detection
- 🔴 PMID 42772943 · Evaluating the predictive value of multiple rounds of faecal haemoglobin measu · 8/10 · Targeted referral of the highest risk individuals enables earlier detection with limited impact on colonoscopy capa.
- ⬜ PMID 42772875 · Where do delays occur? A systematic review of the barriers to early breast can · 8/10 · Community awareness, culturally grounded education, streamlined referral pathways and equitable investment in diagn.
- ⬜ PMID 42769899 · The evolving role of radiotherapy in oligometastatic pancreatic cancer: from p · 8/10 · The TREX1/cGAS-STING axis provides a mechanistic rationale for combining SBRT with immune checkpoint inhibitors, th.
- ⬜ PMID 42769891 · Resistance Mechanisms in Immunotherapy-Radiotherapy/Chemotherapy Combinations · 8/10 · Novel immune checkpoints and adoptive cellular therapies, alongside personalized and adaptive trial designs, offer.
- 🔴 PMID 42771607 · Spectrum and immunovirological determinants of tumours among people living wit · 7/10 · CONCLUSIONS: HIV-associated tumours in this Ugandan cohort remain predominantly malignant and are dominated by KS d.
- 🔴 PMID 42771539 · Neoplasms of the Cervical Spine: Diagnostic Workup and Clinical Decision-makin · 6/10 · Tissue biopsy remains central to diagnosis, with indications, contraindications, and technique selection guided by.
- 🔴 PMID 42772256 · Molecular surgery in colorectal cancer: Integrating genomics into operative de · 5/10 · CRC provides a timely model in which surgery is increasingly shaped not only by anatomical resectability, but also.
- 🔴 PMID 42770557 · Overcoming Steric Hindrance for Precise Multiplexed Protein Profiling of Singl · 5/10 · This approach significantly enhanced the detection of dual-protein-positive EV subpopulations by mitigating mutual.
- 🔴 PMID 42769930 · Exosome-mediated metabolic-immune regulatory axis: mechanisms of gastric cance · 5/10 · Conversely, exosomes released by cancer-associated fibroblasts, tumor-associated macrophages, and mesenchymal strom.
AI and ML in clinical diagnostics
- ⬜ PMID 42773090 · Artificial Intelligence Triage of Urgent Versus Non-Urgent CT Brain Findings t · 8/10 · Preliminary results provide the safety rationale to proceed with a prospective trial aiming to incorporate this tec.
- ⬜ PMID 42772752 · Development and Validation of a Machine Learning-Based Model for Predicting Al · 8/10 · CONCLUSIONS: Our machine learning-based model provides accurate all-cause mortality prediction for patients with T2.
- ⬜ PMID 42772582 · Integrative profiling of multi-modal plasma cfRNA signatures enables detection · 8/10 · Collectively, multi-modal plasma cfRNA profiling may enable non-invasive breast cancer detection and provide candid.
Precision oncology and genomic medicine
- ⬜ PMID 42771901 · Real-world Experience with Sotorasib in KRAS G12C-Mutated Advanced Non-small C · 9/10 · The UK RWE aligns with the results of CodeBreaK 200.
Novel therapeutics immunotherapy CAR-T
- ⬜ PMID 42772869 · Neoadjuvant QL1706 plus chemotherapy in patients with stage II-IIIB squamous n · 8/10 · The results of this study will be presented to peer-reviewed journals and scientific conferences.
- ⬜ PMID 42772656 · Neoadjuvant antibody-drug conjugates for early-stage breast cancer: A systemat · 8/10 · CONCLUSION: Neoadjuvant ADC-based strategies yield clinically meaningful pCR rates in EBC, with the greatest benefi.
- 🟠 PMID 42773039 · [In vivo CAR-T cells: When the patient becomes their own factory]. · 5/10 · We describe the main delivery platforms under clinical investigation, focusing on lentiviral vectors (LVV) and lipi.
Cardiovascular-metabolic GLP-1 SGLT2
- ⬜ PMID 42772984 · The effects of tirzepatide and semaglutide on clinical and metabolic outcomes · 8/10 · Body weight decreased by -7.73% (-10.70 to -4.76; I CONCLUSIONS: Semaglutide and tirzepatide were associated with i.
- ⬜ PMID 42772885 · Left atrial strain assessment in mitral regurgitation: a systematic review. · 8/10 · As most supporting evidence is retrospective and single-centre, further prospective validation will help establish.
- ⬜ PMID 42772753 · Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in p · 8/10 · METHODS AND RESULTS: The Coated Or Chewable Aspirin in Patients with Established AThErosclerotic Disease and a Hybr.
Aging longevity and population health
- No high-priority finds today (best candidate scored 7/10)
Rare diseases with high unmet need
- No high-priority finds today (best candidate scored 0/10)
Sentinel — Unsolicited High-Priority Finds
- ⬜ PMID 42772021 · Association of robot-assisted radical prostatectomy with improved oncological · 9/10 · CONCLUSION: RARP combined with ADT was significantly associated with improved oncological outcomes in patients with.
- ⬜ PMID 42771768 · Diagnostic Accuracy of AI in Prediction and Assessment of Compromised Free Fla · 9/10 · Nevertheless, the low certainty of evidence, substantial heterogeneity, and limited external validation indicate th.
- ⬜ PMID 42773009 · ERAS protocols and 'step-up' complication management are associated with impro · 8/10 · CONCLUSIONS: Combined ERAS and 'step-up' management was associated with improved safety and recovery after PPTP sup.
- ⬜ PMID 42771946 · GBMM: A graph-based multimodal Mamba model for response prediction in patients · 8/10 · CONCLUSION: These findings suggest that GBMM may provide a useful framework for pretreatment prediction of NICT res.
- ⬜ PMID 42771939 · Clinical development of human vaccine candidates against Shigella flexneri: a · 8/10 · Collectively, the available evidence supports the continued development of several vaccine platforms.
- ⬜ PMID 42771885 · Real-Time Artificial Intelligence Diagnostic Copilot in Simulated Primary Care · 8/10 · These findings support further refinement and prospective evaluation in real clinical workflows before conclusions.
- ⬜ PMID 42771814 · Prevention of Rebleeding in Colonic Diverticular Bleeding Using Orengedokuto: · 8/10 · CONCLUSIONS: If orengedokuto demonstrates a hemostatic effect, it could offer a less invasive alternative to endosc.
General (no watchlist topic match after reclassification)
- ⬜ PMID 42772965 · Intracorporeal Versus Extracorporeal Anastomosis in Minimally Invasive Ileocec · 8/10 · ICA significantly reduced overall postoperative complications compared with ECA (OR: 0.44, 95% CI: 0.28-0.70; CONC.
- ⬜ PMID 42772417 · Ketamine versus Etomidate as an induction agent for tracheal intubation: An up · 8/10 · However, ketamine was associated with a higher risk of post-induction cardiovascular collapse based on a pooled ana.
- ⬜ PMID 42771184 · Clinical effectiveness of Er, Cr: YSGG laser compared with conventional rotary · 8/10 · To compare the clinical efficacy of erbium, chromium-doped yttrium scandium gallium garnet (Er, Cr: YSGG) laser ver.
🟢⚪ STANDARD (5–7) — Top 5 by Topic
Hematologic malignancies
- PMID 42771591 · Soluble BCMA Defines Spatial Phenotypes and Prognosis in Newly Diagnosed Mu · 6/10 · Public Health
- PMID 42771584 · How I Treat: MRD testing to personalize allogeneic HCT for adults with AML. · 5/10 · Drug Development
- PMID 42771583 · Mutant ASXL1 Cooperates with MECOM and BRD4 to Drive Transcriptional Dysreg · 5/10 · Genomics/Precision Medicine
- PMID 42771558 · Mycosis fungoides in a Mexican pediatric series: Clinical, immunophenotypic · 5/10 · Drug Development
- PMID 42773001 · Effects of eccentric upper limbs exercises, added with virtual reality, on · 4/10 · Other
CBC-based diagnostics and ML in hematology
- PMID 42770061 · Classification of Benign Hematogones and B-cell Acute Lymphoblastic Leukemi · 6/10 · Genomics/Precision Medicine
- PMID 42772550 · Leukogram abnormalities as prognostic indicators in birds: association with · 5/10 · Genomics/Precision Medicine
Early cancer detection
- PMID 42772320 · Prevalence of liver fibrosis and steatotic liver disease in community-dwell · 7/10 · Genomics/Precision Medicine
- PMID 42770501 · A Qualitative Exploration of the Decision Not to Take Part in Colorectal Ca · 6/10 · Early Detection
- PMID 42773071 · Risk of Long-Term Airway Sequelae and Mortality in Laryngeal Chondrosarcoma · 5/10 · Drug Development
- PMID 42772748 · Safety-Oriented Benchmarking of Large Language Models in Risk-Based Managem · 5/10 · Genomics/Precision Medicine
- PMID 42772653 · Overcoming Inequity in Cancer Screening: Can Modern Technologies Close the · 5/10 · Early Detection
AI and ML in clinical diagnostics
- PMID 42772683 · Dietary Patterns Are Key Predictors of Cardiovascular Risk Beyond Genetic R · 7/10 · Diagnostics
- PMID 42772657 · fNIRS in Autism Neuroscience: From Replication to Discovery. · 7/10 · Public Health
- PMID 42772604 · From Anatomy to Radiology to Imaging Science: How Images Become Biomarkers · 7/10 · Diagnostics
- PMID 42773068 · A small-data machine learning framework with interpretable scorecards for d · 6/10 · Genomics/Precision Medicine
- PMID 42772888 · Applications of artificial intelligence in dyspnoea management for patients · 6/10 · Genomics/Precision Medicine
Precision oncology and genomic medicine
- PMID 42772292 · Genetic data sharing by clinical laboratories in Canada: A position stateme · 7/10 · Genomics/Precision Medicine
- PMID 42771837 · Transcriptomic Plasticity and Its Spatial Architecture Shape Melanoma Respo · 5/10 · Treatment Innovation
- PMID 42771809 · Elucidating the potential anti-liver cancer mechanisms of the medicinal foo · 5/10 · Other
- PMID 42771801 · [Clinicopathological characteristics of human epidermal growth factor recep · 5/10 · Drug Development
- PMID 42771504 · IRE1α-XBP1s signaling links lipid homeostasis to hypoxic maladaptation and · 5/10 · Genomics/Precision Medicine
Novel therapeutics immunotherapy CAR-T
- PMID 42772459 · LINACS: an ESTRO/OligoCare living systematic review of the safety of concur · 6/10 · Drug Development
- PMID 42772283 · Targeting RPL4 improves the therapeutic efficacy of PD-L1 blockade in liver · 6/10 · Drug Development
- PMID 42772938 · Differential peripheral immune dynamics underlie therapeutic response to ch · 5/10 · Treatment Innovation
- PMID 42772936 · Beyond PD-L1/PD-1: expression of PVR/TIGIT and TNFRSF14/BTLA axes in respon · 5/10 · Drug Development
- PMID 42772859 · Integrative multi-omics landscape and diagnostic-therapeutic modelling of s · 5/10 · Genomics/Precision Medicine
Cardiovascular-metabolic GLP-1 SGLT2
- PMID 42773043 · Early-life atherogenesis: Mechanistic pathways, risk architecture, and clin · 7/10 · Other
- PMID 42772699 · Clinical Utilization of CYP17A1 and CYP11B2 in Evaluating Cortisol- and Ald · 7/10 · Genomics/Precision Medicine
- PMID 42772601 · Impact of type 2 diabetes on myocardial mechanics, fibrosis, and prognosis · 7/10 · Genomics/Precision Medicine
- PMID 42772598 · Prognostic value of the Edmonton Obesity Staging System among people hospit · 7/10 · Prevention
- PMID 42772870 · Systematic review of cost-effectiveness analyses of weight loss interventio · 6/10 · Prevention
Aging longevity and population health
- PMID 42771531 · [Suspicion of sarcopenia as a predictor of toxicity in older people with ca · 7/10 · Drug Development
- PMID 42772739 · Early Adoption of Digital Devices and Change in Loneliness Over 10 Years Am · 6/10 · Genomics/Precision Medicine
- PMID 42771595 · [Impact of sarcopenia risk on the functionality of older adults after emerg · 6/10 · Other
- PMID 42773075 · Sex-Specific Cut-off Values for Respiratory Muscle Strength in Older Women: · 5/10 · Public Health
- PMID 42772944 · Clinical characteristics and treatment patterns of elderly versus non-elder · 5/10 · Genomics/Precision Medicine
💡 UNSOLICITED FINDS
- PMID 42772021 · Association of robot-assisted radical prostatectomy with improved oncological · 9/10 · CONCLUSION: RARP combined with ADT was significantly associated with improved oncological outcomes in patients.
- PMID 42771768 · Diagnostic Accuracy of AI in Prediction and Assessment of Compromised Free Fla · 9/10 · Nevertheless, the low certainty of evidence, substantial heterogeneity, and limited external validation indica.
- PMID 42773009 · ERAS protocols and 'step-up' complication management are associated with impro · 8/10 · CONCLUSIONS: Combined ERAS and 'step-up' management was associated with improved safety and recovery after PPT.
- PMID 42771946 · GBMM: A graph-based multimodal Mamba model for response prediction in patients · 8/10 · CONCLUSION: These findings suggest that GBMM may provide a useful framework for pretreatment prediction of NIC.
- PMID 42771939 · Clinical development of human vaccine candidates against Shigella flexneri: a · 8/10 · Collectively, the available evidence supports the continued development of several vaccine platforms.
📊 TODAY'S BREAKDOWN
By research category:
- Genomics/Precision Medicine: 38
- Drug Development: 21
- Other: 13
- Early Detection: 10
- Public Health: 9
- Diagnostics: 6
- Treatment Innovation: 5
- Prevention: 5
By evidence maturity:
- Exploratory: 68
- Validated: 27
- Potentially Practice-Changing: 12
By watchlist topic (reviewed / topic-matched / highest score):
- Hematologic malignancies: 15 reviewed / 10 kept / best=6
- CBC-based diagnostics and ML in hematology: 2 reviewed / 2 kept / best=6
- Early cancer detection: 15 reviewed / 15 kept / best=8
- AI and ML in clinical diagnostics: 15 reviewed / 15 kept / best=8
- Precision oncology and genomic medicine: 15 reviewed / 14 kept / best=9
- Novel therapeutics immunotherapy CAR-T: 15 reviewed / 15 kept / best=9
- Cardiovascular-metabolic GLP-1 SGLT2: 15 reviewed / 14 kept / best=8
- Aging longevity and population health: 15 reviewed / 14 kept / best=7
- Rare diseases with high unmet need: 0 reviewed / 0 kept / best=0
By source type:
- peer_reviewed: 107
- preprint: 0
Topics with zero HIGH articles today: Hematologic malignancies, CBC-based diagnostics and ML in hematology, Aging longevity and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- CRDT window: 2026-09-22T09:00:00Z → 2026-09-23T09:00:00Z (1-day default; no expansion needed).
- 107 unique PMIDs retrieved across all topics; ESummary 107/107, EFetch 107/107 (100% coverage).
- Rare diseases with high unmet need: zero primary-query results; no fallback defined for this topic per task rules.
- CBC-based diagnostics and ML: 2 results only (below 5-record threshold). No window expansion triggered because aggregate multi-topic results exceeded 5 records.
- Topic reclassification: 5 ESearch false positives corrected — PMIDs 42772965 (colorectal surgery), 42772417 (anesthesia meta-analysis), 42772634 (pelvic pain NMA), 42773014 (nursing pain mgmt), and 42771184 (pediatric dentistry) removed from incorrect watchlist buckets; scores unchanged.
- Flag corrections: PMIDs 42769899 and 42769891 had initial EARLY_CANCER_DETECTION misclassification (radiotherapy/resistance papers); corrected to NONE; both remain HIGH by score ≥8.
- Protocol paper: PMID 42771875 downscored from 9→7 (protocol with no results; Exploratory evidence maturity).
- No preprints detected in this window.
- No truncation beyond per-topic 15-candidate cap.
- Scoring version: v2 with conservative flag assignment.