Management of immune-related cutaneous adverse events associated with…
OBJECTIVES: This study aims to systematically retrieve and synthesise the best available evidence on the management of immune-related cutaneous adverse events (ircAEs) associated with immune checkpoint inhibitors (ICIs) in patients with cancer, there. CONCLUSIONS: The evidence provides a structured basis for standardising ircAEs screening, nursing assessment, symptom management, referral and follow-up in patients receiving ICIs.
- Lab
- Preclinical
- Early trials
- Late trials
- In practice
Sustained proton-pump inhibitor exposure and incident age-related…
OBJECTIVE: Proton-pump inhibitors (PPIs) may disrupt lysosomal acidification, a pathway implicated in age-related macular degeneration (AMD) pathogenesis. The consistency of the active-comparator findings supports the potential specificity of this association and warrants further investigation to determine its clinical implications.
Near-term implementable findingTreatment patterns and outcomes in advanced clear cell sarcoma and…
BACKGROUND: Clear cell sarcoma (CCS) and gastrointestinal neuroectodermal tumor (GNET) are ultra-rare soft tissue sarcomas with no established standard of care for advanced disease. Outcomes remain poor, highlighting the need for novel therapies and collaborative studies.
Near-term implementable findingFeasibility and Clinical Consequences of Liberal Fasting Compared to…
BACKGROUND: Pre-procedural fasting is routinely recommended before coronary angiography and percutaneous coronary intervention (PCI), largely based on guidelines developed for procedures involving sedation or anesthesia. CONCLUSION: In this randomized controlled trial, liberal fasting practices before elective coronary angiography were not associated with an observed increase in short-term adverse events.
Standard additionPacific women's pre-diagnostic experiences of endometrial cancer…
INTRODUCTION: Pacific women are disproportionally affected by endometrial cancer in Aotearoa New Zealand. Equitable healthcare access for Pacific women with endometrial cancer symptoms is critical for timely diagnosis and to reduce negative consequences for endometrial cancer-related morbidity, prognosis.