Daily digest · Fri · 25 Sep 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

AI and ML in clinical diagnostics

42785737 · AI Decision Support for Emergency Triage of Large Vessel Occlusion Using Noncontrast Computed Tomography: Systematic Review and Bayesian Diagnostic Test Accuracy Network Meta-Analysis · 8/10 · Topic: AI and ML in clinical diagnostics

Rare diseases with high unmet need

42784525 · Development of Inno8, an orally administered factor VIIIa-mimetic antibody fragment for treatment of hemophilia A · 6/10 · First-in-human clinical study

Topics with no 8+ articles today:

Hematologic malignancies: No high-priority finds (best candidate: 6/10)
CBC-based diagnostics and ML in hematology: No high-priority finds (best candidate: 6/10)
Early cancer detection: No high-priority finds (best candidate: 5/10)
Precision oncology and genomic medicine: No high-priority finds (best candidate: 6/10)
Novel therapeutics immunotherapy CAR-T: No high-priority finds (best candidate: 7/10)
Cardiovascular-metabolic GLP-1 SGLT2: No high-priority finds (best candidate: 6/10)
Aging longevity and population health: No high-priority finds (best candidate: 6/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies

42785713 · Child Opportunity Index and Survival After Pediatric Hematopoietic Cell Transplantation fo · 6/10 · Treatment Innovation
42783983 · Dematiaceous Fungal Infections in Hematopoietic Stem Cell Transplantation and Predisposing · 5/10 · Treatment Innovation
42786017 · Real-World Experience With Mogamulizumab for Mycosis Fungoides and Sézary Syndrome · 5/10 · Treatment Innovation
42786016 · A Single-center Retrospective Study of MIAD ± R Chemotherapy in Newly Diagnosed Primary Ce · 5/10 · Treatment Innovation
42785226 · PDFormer: A Multimodal Transformer for Quantifying Motor Symptom Severity in Parkinson's D · 5/10 · Treatment Innovation

CBC-based diagnostics and ML in hematology

42779136 · Deep Learning-Assisted Classification of Urinary Red Blood Cell Morphology for Glomerular · 6/10 · Diagnostics
42780108 · Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic · 5/10 · Diagnostics
42780051 · Artificial intelligence prediction of therapy response in newly diagnosed adult severe pri · 5/10 · Diagnostics

Early cancer detection

42781200 · Role of Tei Index in Early Detection of Anthracycline-induced Cardiotoxicity · 5/10 · Early Detection
42783413 · Precision Diagnostics in Prostate Cancer: Integrating Biomarkers, Imaging, Genomics, and A · 5/10 · Early Detection
42781935 · Improving CTC isolation by controlling orbit engagement in inertial microfluidics · 5/10 · Early Detection
42780554 · Vitamin intake and colorectal cancer incidence and mortality: evidence from a large prospe · 5/10 · Early Detection

AI and ML in clinical diagnostics

42785958 · Predicting disease flares in axial spondyloarthritis using different machine learning mode · 6/10 · Diagnostics
42785829 · Development and validation of AI-based chatbot for self-management in liver transplant rec · 6/10 · Diagnostics
42785566 · Efficient and accurate tuberculosis diagnosis: Attention Residual U-Net and vision transfo · 6/10 · Diagnostics
42785552 · Cost-Effectiveness and Clinical Utility of a Retinal Cardiovascular AI-Guided Strategy for · 6/10 · Diagnostics
42786109 · Optimizing 3D FLAIR imaging of endolymphatic hydrops: Benefits and limitations of deep lea · 5/10 · Diagnostics

Precision oncology and genomic medicine

42785914 · HER1-HER4 expression and co-expression in advanced urothelial carcinoma · 6/10 · Genomics/Precision Medicine
42786066 · Pretreatment Tumor NECTIN4 RNA Expression Is Associated with First-line Enfortumab Vedotin · 5/10 · Genomics/Precision Medicine
42785954 · Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personali · 5/10 · Genomics/Precision Medicine
42785953 · Renal Function Decline After (177)Lu-PSMA-617 Versus Taxane-Based Chemotherapy in Patients · 5/10 · Genomics/Precision Medicine
42785951 · Association of ATM Alterations with Outcomes After (177)Lu-PSMA-617 Treatment in Patients · 5/10 · Genomics/Precision Medicine

Novel therapeutics immunotherapy CAR-T

42785163 · Atezolizumab plus pertuzumab, trastuzumab, and chemotherapy in HER2-positive early breast · 7/10 · Treatment Innovation
42785981 · Expert consensus on clinical trials for use of systemic therapy in patients with hepatocel · 6/10 · Treatment Innovation
42785920 · Toward precision adjuvant immunotherapy in high-risk clear cell renal cell carcinoma: inte · 5/10 · Treatment Innovation
42785689 · Screening strong anaerobic E. coli promoters to enhance therapeutical protein expression i · 5/10 · Treatment Innovation
42785687 · Physiologically adaptive prodrug liposomal nanoplatform enables programmable biointerface · 5/10 · Treatment Innovation

Cardiovascular-metabolic GLP-1 SGLT2

42786013 · Tocilizumab enhances HDL functionality in rheumatoid arthritis: A 6-month prospective stud · 6/10 · Treatment Innovation
42785601 · Platelet-to-high-density lipoprotein cholesterol ratio and risk of major adverse cardiovas · 6/10 · Treatment Innovation
42785724 · Intersectional Effects of the FIT FIRST 10 School-Based Intervention Across Sex and Parent · 5/10 · Treatment Innovation
42785671 · Clinical outcomes associated with glucagon-like peptide-1 receptor agonist therapy in pati · 5/10 · Treatment Innovation
42785638 · Hemoglobinopathies and diabetes mellitus: from pathophysiology to clinical practice · 5/10 · Treatment Innovation

Aging longevity and population health

42783369 · Childhood Adversity and Health in Emerging Adulthood · 6/10 · Public Health
42784692 · Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in can · 5/10 · Public Health
42784539 · Exploring clinical reasoning in physical and occupational therapists treating frail older · 5/10 · Public Health
42783913 · The Brown Algal Phlorotannin Dieckol Attenuates Amyloid-β Oligomer-Induced Oxidative DNA D · 5/10 · Public Health
42783416 · From Neonatal History to Adult Cardiovascular Risk: Preterm Birth as a Lifelong Risk Enhan · 5/10 · Public Health

Rare diseases with high unmet need

42784867 · Safety and tolerability of anselamimab in participants with light chain amyloidosis: Resul · 7/10 · Treatment Innovation
42785298 · Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene the · 6/10 · Treatment Innovation
42784360 · Impact of Gene Therapy on the Haemophilia-Free Mind: Outcomes Before and After Valoctocoge · 6/10 · Treatment Innovation
42783356 · DNA Nanoassembly Modified Polydopamine@MnO(2) Nanoparticles: Enhancement of miRNA-21 Downr · 6/10 · Treatment Innovation
42782615 · Analytical Study Showing a False-Negative Limitation of Deletion-Based Newborn Screening f · 6/10 · Treatment Innovation

Unsolicited / Sentinel

42786131 · Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: · 6/10 · Other
42786114 · Hyperthermic intraperitoneal chemotherapy is associated with improved overall survival in · 6/10 · Other
42786113 · Integrating deep learning-based radiographic features with demographic variables for hip o · 5/10 · Other
42786089 · Adrenalectomy for adrenocortical carcinoma: A national assessment of trends in the utiliza · 5/10 · Other
42786087 · Factors associated with successful nonoperative management of colonic fistulas from necrot · 5/10 · Other

💡 UNSOLICITED FINDS

42786131 · Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: · 6/10
42786114 · Hyperthermic intraperitoneal chemotherapy is associated with improved overall survival in · 6/10
42786113 · Integrating deep learning-based radiographic features with demographic variables for hip o · 5/10
42786089 · Adrenalectomy for adrenocortical carcinoma: A national assessment of trends in the utiliza · 5/10
42786087 · Factors associated with successful nonoperative management of colonic fistulas from necrot · 5/10

📊 TODAY'S BREAKDOWN

By research category:

Treatment Innovation: 58
Diagnostics: 19
Public Health: 15
Genomics/Precision Medicine: 13
Early Detection: 12
Other: 9

By evidence maturity:

Validated: 78
Exploratory: 46
Potentially Practice-Changing: 2

By watchlist topic (reviewed / kept ≥5 / highest score):

Hematologic malignancies: 15 reviewed (raw 70) / 11 scored ≥5 / best 6/10
CBC-based diagnostics and ML in hematology: 5 reviewed (raw 5) / 4 scored ≥5 / best 6/10
Early cancer detection: 12 reviewed (raw 12) / 11 scored ≥5 / best 5/10
AI and ML in clinical diagnostics: 15 reviewed (raw 196) / 14 scored ≥5 / best 8/10
Precision oncology and genomic medicine: 15 reviewed (raw 47) / 12 scored ≥5 / best 6/10
Novel therapeutics immunotherapy CAR-T: 15 reviewed (raw 46) / 12 scored ≥5 / best 7/10
Cardiovascular-metabolic GLP-1 SGLT2: 15 reviewed (raw 94) / 15 scored ≥5 / best 6/10
Aging longevity and population health: 15 reviewed (raw 26) / 8 scored ≥5 / best 6/10
Rare diseases with high unmet need: 15 reviewed (raw 63) / 10 scored ≥5 / best 7/10
Sentinel scan: 10 reviewed / best 6/10

By source type: peer_reviewed 126 | preprint 0

Topics with zero 8+ articles: Hematologic malignancies, CBC-based diagnostics and ML in hematology, Early cancer detection, Precision oncology and genomic medicine, Novel therapeutics immunotherapy CAR-T, Cardiovascular-metabolic GLP-1 SGLT2, Aging longevity and population health

🔧 RUN NOTES

Window: 1-day CRDT incremental (2026-09-24T09:00:00Z → 2026-09-25T09:00:00Z)
126 unique PMIDs fetched across 9 watchlist topics + sentinel scan
ESummary: 126/126 | EFetch: 126/126 — full coverage, no missing records
No window expansion triggered (all topics returned ≥5 relevant candidates)
CBC-based diagnostics and ML in hematology: only 5 candidates (raw count 5); cap not hit
Early cancer detection: only 12 candidates (raw count 12); cap not hit
Post-scoring corrections applied: 7 articles — case reports capped at ≤4, narrative reviews capped novelty ≤1, EARLY_CANCER_DETECTION flag removed from reviews and case reports
All abstract-based classification; no PMC full-text fetched this run
Attempt 1 of 3