AI Decision Support for Emergency Triage of Large Vessel Occlusion…
BACKGROUND: Emergency triage of anterior circulation large vessel occlusion (LVO) is constrained by delays in vascular imaging, specialist interpretation, and transfer decision-making. The evidence remains accuracy based and does not establish workflow effectiveness, reperfusion acceleration, or functional outcome benefit.
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Atezolizumab plus pertuzumab, trastuzumab, and chemotherapy in…
BACKGROUND: The IMpassion050 (NCT03726879) primary analysis showed similar pathologic complete response (pCR) rates with/without the addition of neoadjuvant atezolizumab to pertuzumab, trastuzumab, and chemotherapy in high-risk human epidermal growth factor receptor 2-positive early breast cancer in the intention-to-treat and programmed death-ligand 1 (PD-L1)-positive populations. CONCLUSIONS: There were no significant improvements in 3-year EFS (stratified hazard ratio: 0.90; 95% CI: 0.50-1.59) or DFS (unstratified hazard ratio: 0.71; 95% CI: 0.38-1.32) rates with the addition of atezolizumab.
Near-term implementable findingSafety and tolerability of anselamimab in participants with light…
BACKGROUND: Light chain (AL) amyloidosis is a rare, potentially fatal plasma cell dyscrasia (PCD). Most common TEAEs were consistent with AL amyloidosis or anti-PCD therapy.
Near-term implementable findingChild Opportunity Index and Survival After Pediatric Hematopoietic…
BACKGROUND: Despite advances in pediatric hematopoietic cell transplantation (HCT) for acute leukemia, many children still experience relapse and non-relapse mortality (NRM). 7%) were higher among those in very low opportunity neighborhoods but were not statistically significant.
Promising but preliminaryDeep Learning-Assisted Classification of Urinary Red Blood Cell…
BACKGROUND: Distinguishing glomerular from non-glomerular hematuria remains challenging because urinary dysmorphic red blood cells (RBCs) are morphologically heterogeneous and affected by preanalytical and physicochemical factors. Multicenter validation with independent clinical reference standards is required before clinical implementation.