Small Activating RNAs: A Curated Database and an Overview of Rational Design Principles.
RNA activation (RNAa), mediated by small activating RNAs (saRNAs), upregulates endogenous gene expression through recruitment of the Argonaute proteins to the promoter, natural antisense transcripts, or other noncoding RNAs. Consolidation of saRNA records into a unified resource will hopefully enable systematic analysis of sequence features associated with activity and lay a foundation for moving saRNA design from largely empirical screening toward more rational design.
RNA activation (RNAa), mediated by small activating RNAs (saRNAs), upregulates endogenous gene expression through recruitment of the Argonaute proteins to the promoter, natural antisense transcripts, or other noncoding RNAs. Consolidation of saRNA records into a unified resource will hopefully enable systematic analysis of sequence features associated with activity and lay a foundation for moving saRNA design from largely empirical screening toward more rational design.
What the study was
- Study design
- Review
- Population
- RNA activation (RNAa), mediated by small activating RNAs (saRNAs), upregulates endogenous gene expression through recruitment of the Argonaute proteins to the promoter, natural antisense transcripts, or other noncoding RNAs.
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Molecules (Basel, Switzerland)
Why it surfaced
Review with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
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