Venetoclax-Based Regimens in Newly Diagnosed FLT3-Mutated Older or…
Older or medically unfit patients with newly diagnosed FLT3-mutated acute myeloid leukemia (AML) have poor outcomes with hypomethylating agent (HMA) monotherapy. On current evidence, triplets are a promising biologically rational strategy requiring direct randomized validation against the contemporary VEN-HMA standard.
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- Preclinical
- Early trials
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- In practice
Multi-target blood test for hepatocellular carcinoma early detection
BACKGROUND & Globally, 350 million people are at risk for HCC. In this prospective multicenter study, a multi-target HCC blood test demonstrated substantially higher sensitivity for early-stage HCC detection than ultrasound while maintaining favorable screening performance across diverse patient subgroups.
Near-term implementable findingVascular Ehlers-Danlos syndrome
Vascular Ehlers-Danlos syndrome (vEDS), caused by likely pathogenic COL3A1 variants, carries a high risk of arterial dissection or rupture, intestinal perforation and uterine rupture, and a median survival near 51 years. In vEDS, earlier recognition and the avoidance of iatrogenic harm-not new molecules-offer the largest near-term gains in survival and quality of life.
Standard additionPooled Individual Patient-Data Analysis of Clinical Trials on…
We aim to study the outcomes of second-line MKIs via combined analyses of the three studies. Given the strong prognostic signal of MVI observed in this analysis, our data suggest considering MVI, rather than prior response to immunotherapy or EHS, as a stratification factor for future second-line trials.
Novel or significantly improved treatmentReal-World Comparison of Axicabtagene Ciloleucel and Lisocabtagene…
Axicabtagene ciloleucel (axi-cel) and lisocabtagene maraleucel (liso-cel) are approved chimeric antigen receptor (CAR) T-cell therapies for relapsed/refractory large B-cell lymphoma (r/r LBCL). These findings should be interpreted cautiously given differential follow-up between treatment groups and the potential for residual confounding.