📅 PUBMED DAILY TRIAGE — 2026-09-27 Window: 2026-09-26T09:00:00Z → 2026-09-27T09:00:00Z (CRDT) Topics scanned: 9 + sentinel | Articles reviewed: 116 | Candidates evaluated: 133 High priority: 6 | Standard: 100 | Low/archive: 10 | Unsolicited finds: 4 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies
42800061 · Venetoclax-Based Regimens in Newly Diagnosed FLT3-Mutated Older or Unfit Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis of Comparative and Single-Arm Outcomes. · 9/10 · Meta-analysis with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need. 42800585 · Real-World Comparison of Axicabtagene Ciloleucel and Lisocabtagene Maraleucel in Relapsed/Refractory Large B-Cell Lymphoma: A Target Trial Emulation. · 8/10 · Observational cohort study with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 6/10).
Early cancer detection
42800682 · Multi-target blood test for hepatocellular carcinoma early detection: a cross-sectional analysis of the prospective ALTUS study. · 9/10 · Cross-sectional study with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
AI/ML in clinical diagnostics and imaging
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 7/10).
Precision oncology and genomic medicine
Precision oncology and genomic medicine: No high-priority finds today (best candidate scored 7/10).
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42800585 · Real-World Comparison of Axicabtagene Ciloleucel and Lisocabtagene Maraleucel in Relapsed/Refractory Large B-Cell Lymphoma: A Target Trial Emulation. · 8/10 · Observational cohort study with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need. 42800536 · Pooled Individual Patient-Data Analysis of Clinical Trials on Second-line Multikinase Inhibitors Following Immunotherapy in Hepatocellular Carcinoma. · 8/10 · Observational cohort study with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health
42800747 · DEED-FRAIL trial: A cluster-randomized trial of a frailty-oriented multicomponent ED discharge intervention for older adults with geriatric vulnerability and acute heart failure. · 8/10 · Randomized controlled trial with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
Rare diseases with high unmet need
42798186 · Vascular Ehlers-Danlos syndrome: A multidisciplinary clinical framework for early suspicion, emergency-safe management and lifelong care. · 8/10 · Review with abstract evidence; scored conservatively for novelty, clinical relevance, design quality, and population or unmet need.
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
42798610 · Intraoperative traction in posterior spinal fusion for adolescent idiopathic scoliosis: an updated systematic review and meta-analysis of correction, perioperative, and safety outcomes. · 7/10 · Genomics/Precision Medicine 42798608 · Leucine, autoimmune diseases, and circulating mediators shape the causal landscape of lymphoid malignancies. · 7/10 · Treatment Innovation 42800596 · Reassessing the Clinical Value of Momelotinib in Myelofibrosis: An ESMO-MCBS:H-Based Appraisal of SIMPLIFY-1 and MOMENTUM. · 7/10 · Treatment Innovation 42800398 · Age over sibling: Younger unrelated donors provide superior outcomes compared to sibling donors in fully matched HCT in older AML/MDS patients. · 7/10 · Public Health 42800058 · Impact of Residual Disease Localization Before Allogeneic Hematopoietic Stem Cell Transplantation on Outcomes in Adult T-Cell Leukemia-Lymphoma. · 7/10 · Other
CBC-based diagnostics and machine learning in hematology
42798567 · Nurse-coordinated biomarker and symptom monitoring for immune checkpoint inhibitor toxicity. · 6/10 · Treatment Innovation 42796724 · Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review. · 5/10 · Diagnostics
Early cancer detection
42799245 · Early-Stage Predominance in Breast Cancer Diagnosis Among a Rural Population: Associations With Smoking Status in a 10-Year Registry-Based Cohort Study. · 7/10 · Early Detection 42799080 · Radiomics in spinal research: a narrative review. · 7/10 · Early Detection 42798930 · Postoperative circulating tumor DNA in stage II colon cancer: biological rationale, clinical evidence, and unresolved challenges. · 7/10 · Early Detection 42798918 · Generative artificial intelligence in lung cancer care: current applications, challenges, and future directions. · 7/10 · Early Detection 42798840 · Integrative multi-omics profiling and machine learning reveal enhancer RNA signatures for early detection and prognostic stratification in breast cancer. · 7/10 · Early Detection
AI/ML in clinical diagnostics and imaging
42799080 · Radiomics in spinal research: a narrative review. · 7/10 · Early Detection 42799059 · Integrating hyperspectral features and physiological parameters for quantitative estimation of fig rust severity. · 7/10 · Early Detection 42799479 · Identification and Preliminary mRNA Validation of Key Genes Associated with Tolerogenic Dendritic Cells in Keloid Based on Transcriptome Data. · 6/10 · Genomics/Precision Medicine 42799473 · Rational High-Throughput Screening of Cocrystals: An Explainable Deep Learning Framework Based on Morgan Fingerprints and Cross-Attention. · 6/10 · Early Detection 42799385 · Evaluating the correspondence of neuropsychological profiles with clinical diagnostic criteria for frontotemporal lobar degeneration and Alzheimer's disease: insights from k-means clustering. · 6/10 · Genomics/Precision Medicine
Precision oncology and genomic medicine
42799200 · A Single-Cell-Derived CD8+ T-Cell State Plasticity Score for Prognostic Stratification and Characterization of Immune Responsiveness in Hepatocellular Carcinoma. · 7/10 · Treatment Innovation 42798965 · Robotic vs. Laparoscopic Stapling in Robotic Total Mesorectal Excision: A Prospective Cohort Study. · 7/10 · Genomics/Precision Medicine 42798930 · Postoperative circulating tumor DNA in stage II colon cancer: biological rationale, clinical evidence, and unresolved challenges. · 7/10 · Early Detection 42798918 · Generative artificial intelligence in lung cancer care: current applications, challenges, and future directions. · 7/10 · Early Detection 42798865 · Integrated analysis identified MARK4 as a prognostic and immunomodulatory biomarker in oral squamous cell carcinoma. · 7/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
42799097 · Initiation of immune checkpoint inhibitor therapy in winter is associated with improved overall survival in patients with advanced non-small cell lung cancer. · 7/10 · Treatment Innovation 42798121 · Peripheral blood markers predict prognosis in patients with advanced non-small cell lung cancer receiving immunotherapy. · 7/10 · Treatment Innovation 42797493 · Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors. · 7/10 · Treatment Innovation 42798542 · Prognostic impact of HLA-G expression in cervical squamous cell carcinoma: correlation with PD-L1 and CD8-positive tumor infiltrating lymphocytes. · 6/10 · Genomics/Precision Medicine 42800661 · The circulating tumor microenvironment in small-cell lung cancer: Vimentin-positive circulating tumor endothelial cells as drivers of metastasis and poor prognosis in a large cohort study. · 6/10 · Early Detection
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
42799462 · Impact of Multimorbidity on Mental Illness in the United Arab Emirates: A Review. · 7/10 · Early Detection 42799284 · Rapid Treatment of Acute Decompensated Heart Failure with Cardiogenic Shock in the Emergency Setting. · 7/10 · Treatment Innovation 42799241 · Stress-Induced Cardiomyopathy Following Elective Lumbar Disc Nucleotomy: Multimodal Cardiac Evaluation With 2D-STE and D-SPECT in a Patient With Severe Cardiac Magnetic Resonance (CMR) Contraindication. · 7/10 · Treatment Innovation 42799053 · Investigating seizures in bariatric surgery patients: Pre- and postoperative perspectives: A systematic review. · 7/10 · Other 42798836 · Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics. · 7/10 · Genomics/Precision Medicine
Aging, longevity, and population health
42799450 · Development and validation of a risk prediction model for postoperative frailty in breast cancer patients. · 7/10 · Treatment Innovation 42799044 · Association of frailty indices with post-operative outcomes in shoulder surgery: a systematic review. · 7/10 · Public Health 42798817 · Navigating TIPS in the era of ageing and metabolic comorbidity: a contemporary narrative review of risk, resilience, and outcomes. · 7/10 · Public Health 42798525 · Study of Comparison of Handgrip Dynamometer and Transverse Psoas Muscle Thickness as a Predictor of Short-term Morbidity and Mortality in Patients of Chronic Liver Disease. · 7/10 · Public Health 42798462 · Factors associated with sarcopenia in elderly patients with type 2 diabetes mellitus. · 7/10 · Early Detection
Rare diseases with high unmet need
42797641 · Nucleos(t)ide Analog-Therapeutic Vaccination Switch: A Novel Approach for Safe and Effective Treatment Discontinuation in HBeAg (-) Chronic Hepatitis B Patients. · 7/10 · Treatment Innovation 42796538 · Small Activating RNAs: A Curated Database and an Overview of Rational Design Principles. · 7/10 · Early Detection 42798575 · Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies. · 6/10 · Treatment Innovation 42796319 · Venous Thromboembolism in Neonates, Children, and Adolescents: A Comprehensive Narrative Review of Risk Factors, Diagnosis, Treatment, and Prevention. · 6/10 · Treatment Innovation 42794712 · Artificial Intelligence in Pediatric Cardiovascular Genetics: From Multimodal Diagnosis to Risk Prediction and Precision Therapeutics. · 6/10 · Treatment Innovation
💡 UNSOLICITED FINDS
42799105 · Climate change, environmental exposures, and breast cancer: advancing climate-resilient oncology through sustainable development goal 13. · 7/10 42799154 · COMPARATIVE ANALYSIS OF CULTIVATION TECHNIQUES FOR MCF-7 TUMOR CELLS: AGAROSE SEEDING, ALGINATE MIXING, AND 3D BIOPRINTING. · 7/10 42799518 · Diabetic Autonomic Neuropathy Among Patients With Diabetes in Rural Warangal in India: A Cross-Sectional Study. · 7/10
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics 7 | Early Detection 24 | Genomics/Precision Medicine 15 | Other 17 | Prevention 1 | Public Health 5 | Treatment Innovation 47
- By evidence maturity: Exploratory 72 | Validated 44
- By watchlist topic:
- Hematologic malignancies: 15 reviewed / 15 classified / highest 9
- CBC-based diagnostics and machine learning in hematology: 3 reviewed / 3 classified / highest 6
- Early cancer detection: 15 reviewed / 15 classified / highest 9
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 15 classified / highest 7
- Precision oncology and genomic medicine: 15 reviewed / 15 classified / highest 7
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 15 classified / highest 8
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 15 classified / highest 7
- Aging, longevity, and population health: 15 reviewed / 15 classified / highest 8
- Rare diseases with high unmet need: 15 reviewed / 15 classified / highest 8
- Sentinel: 10 reviewed / 10 classified / highest 7
- By source type: peer_reviewed 116 | preprint 0
- Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, AI/ML in clinical diagnostics and imaging, Precision oncology and genomic medicine, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
🔧 RUN NOTES
- Complete 24-hour CRDT window; no expansion triggered.
- Per-topic cap was 15; sentinel cap was 10.
- All selected PMIDs were present in ESummary and EFetch; records without abstracts were classified from title/metadata and capped conservatively.
- Same-date rerun rebuilt the full corpus; duplicate Telegram alerts were suppressed and none were sent by this attempt.